New sedative in intensive care, Dexmedetomidine hydrochloride (Precedex), its pharmacological characteristics and clinical study result
نویسندگان
چکیده
منابع مشابه
Dexmedetomidine hydrochloride as a long-term sedative
Dexmedetomidine undoubtedly is a useful sedative in the intensive care setting because it has a minimal effect on the respiratory system. Dexmedetomidine infusions lasting more than 24 hours have not been approved since the first approval was acquired in the US in 1999. However, in 2008, dexmedetomidine infusions for prolonged use were approved in Colombia and in the Dominican Republic, and the...
متن کاملClinical application, the use of dexmedetomidine in intensive care sedation
Optimal sedation strategy in the critically ill should achieve effective analgesia, targeted sedation and reduced risk of delirium and agitation. Whilst there is no single agent that can achieve these goals for all patients, a multimodal approach may optimise the use of different agents through multiple modes of action and reduce possible adverse events. This practice review provides an evidenc...
متن کاملDexmedetomidine: Sedative and Neuroprotective Mechanisms of Action and New Developments
Dexmedetomidine, the D-enantiomer of medetomidine, is among the most potent sedative drugs known. It is also one of the best understood in terms of its molecular and cellular mechanisms. Its sedative (and probably its neuroprotective) effects are mediated by subtype A of the α2 adrenergic receptor, a G-protein-coupled receptor. Acting as an agonist at this receptor, dexmedetomidine causes numer...
متن کاملDexmedetomidine: current role in anesthesia and intensive care.
BACKGROUND AND OBJECTIVES To update and review the application of dexmedetomidine in anesthesia and intensive care. This study is a comprehensive review of clinical uses, pharmacology, pharmacokinetics, mechanism of action and adverse effects of dexmedetomidine. CONTENT The effective use of sedative-hypnotic agents and analgesics is an integral part of comfort and safety of patients. Dexmedet...
متن کاملClinical characteristics and outcome of severe melioidosis requiring intensive care.
STUDY OBJECTIVE To describe the clinical characteristics and outcome of patients with severe melioidosis requiring intensive care. DESIGN Retrospective chart review. SETTING Two ICUs from a tertiary-care teaching hospital. PATIENTS Twenty-seven adult ICU patients with microbiologically documented melioidosis. INTERVENTIONS None. MEASUREMENTS AND RESULTS The median age was 59 years wit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2004
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.124.171